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Professor
Nilesh Samani (pubs from 1996)
Genome-wide association study identifies novel genes for biomarkers of cardiovascular disease:
serum urate and dyslipidemia
Am J Hum Genet. 2008 Jan 10; 82(1) pp. 139 - 149
Chris Wallace; Stephen J Newhouse; Peter Braund; Feng Zhang; Martin Tobin; Mario
Falchi; Kourosh Ahmadi; Richard J Dobson; Ana Carolina B Marçano; Cother Hajat; Paul Burton; Panagiotis
Deloukas; Morris Brown; John M Connell; Anna Dominiczak; G Mark Lathrop; John Webster; The Wellcome
Trust Case Control Consortium; Martin Farrall; Tim Spector; Nilesh J Samani; Mark J Caulfield; Patricia B.
Munroe
Genomewide association analysis of coronary artery disease.
N Engl J Med. 2007 Aug 2;357(5):443-53. Epub 2007 Jul 18.
Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H, WTCCC
Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
J Med Genet. 2007 Jun 8; [Epub ahead of print]
Braga Marcano AC, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D, Brown M, Dominiczak A, Connell JM, Webster J,
Lathrop M, Caulfield M, Samani N, Gauguier D, Munroe PB.
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Nature. 2007 Jun 7;447(7145):661-78.
Wellcome Trust Case Control Consortium.
Chris Wallace, Ming-Zhan Xue, Stephen J. Newhouse, Ana Carolina B. Marçano, Abiodun K. Onipinla, Beverley Burke, Johannie Gungadoo, Richard J. Dobson, Morris Brown, John M. Connell, Anna Dominiczak, G. Mark Lathrop, John Webster, Martin Farrall, Charles Mein, Nilesh J. Samani, Mark J. Caulfield, David G. Clayton, and Patricia B. Munroe
Linkage Analysis Using Co-Phenotypes in the BRIGHT Study Reveals Novel Potential Susceptibility Loci for Hypertension.
Am J Hum Genet. 2006 Aug;79(2):323-31. Epub 2006 Jun 19.
Munroe PB, Wallace C, Xue MZ, B Marcano AC, Dobson RJ, Onipinla AK, Burke B, Gungadoo J, Newhouse SJ, Pembroke J, Brown M, Dominiczak AF, Samani NJ, Lathrop M, Connell J, Webster J, Clayton D, Farrall M, Mein CA, Caulfield M
Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study.
Hypertension. 2006 Jun 5; [Epub ahead of print]
Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D, Samani N, Dominiczak A, Webster J, Lathrop GM, Connell J, Munroe P, Caulfield M, Farrall M.
Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension.
Hum Mol Genet. 2006 Apr 15;15(8):1365-74. Epub 2006 Mar 16
Sandosh Padmanabhan PhD, Chris Wallace Ph.D, Patricia B. Munroe Ph.D, Richard Dobson BSc, Morris Brown F.R.C.P, Nilesh Samani F.R.C.P,
David Clayton B.A, Martin Farrall FRCPath, John Webster F.R.C.P, Mark Lathrop Ph.D, Mark Caulfield F.R.C.P, Anna F. Dominiczak F.R.C.P, John M.
Connell F.R.C.P.
Chromosome 2p shows significant linkage to anti-hypertensive response in the British Genetics of Hypertension (BRIGHT) study.
Hypertension. 2006 Mar;47(3):603-8. Epub 2006 Jan 3.
S.J. Newhouse, C. Wallace, R. Dobson, C. Mein, J. Pembroke, M. Farrall, D. Clayton, M. Brown, N. Samani, A. Dominiczak, J.M. Connell, J. Webster, G.M. Lathrop, M. Caulfield, P. B. Munroe.
Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension (BRIGHT) study.
Human Molecular Genetics. Jul 1;14(13):1805-14. Epub 2005 May 11.
Tobin
MD, Braund PS, Burton PR, Thompson JR, Steeds R, Channer K,
Cheng S, Lindpaintner K, Samani NJ.
Genotypes and haplotypes predisposing to myocardial infarction:
a multilocus case-control study.
Eur Heart J. 2004 Mar;25(6):459-67.
Helgadottir
A, Manolescu A, Thorleifsson G, Gretarsdottir S, Jonsdottir
H, Thorsteinsdottir U, Samani NJ, Gudmundsson G, Grant SF, Thorgeirsson
G, Sveinbjornsdottir S, Valdimarsson EM, Matthiasson SE, Johannsson
H, Gudmundsdottir O, Gurney ME, Sainz J, Thorhallsdottir M,
Andresdottir M, Frigge ML, Topol EJ, Kong A, Gudnason V, Hakonarson
H, Gulcher JR, Stefansson K. The gene encoding 5-lipoxygenase
activating protein confers risk of myocardial infarction and
stroke.
Nat Genet. 2004 Mar;36(3):233-9.
Rigatti
R, Jia JH, Samani NJ, Eperon IC.
Exon repetition: a major pathway for processing mRNA of some
genes is allele-specific.
Nucleic Acids Res. 2004 Jan 22;32(2):441-6.
Tiago
AD, Badenhorst D, Nkeh B, Candy GP, Brooksbank R, Sareli P,
Libhaber E, Samani NJ, Woodiwiss AJ, Norton GR.
Impact of renin-angiotensin-aldosterone system gene variants
on the severity of hypertension in patients with newly diagnosed
hypertension.
Am J Hypertens. 2003 Dec;16(12):1006-10.
Sensky
PR, Loubani M, Keal RP, Samani NJ, Sosnowski AW, Galinanes M.
Does the type of prosthesis influence early left ventricular
mass regression after aortic valve replacement? Assessment with
magnetic resonance imaging.
Am Heart J. 2003 Oct;146(4):E13.
Freeman
DJ, Samani NJ, Wilson V, McMahon AD, Braund PS, Cheng S, Caslake
MJ, Packard CJ, Gaffney D.
A polymorphism of the cholesteryl ester transfer protein gene
predicts cardiovascular events in non-smokers in the West of
Scotland Coronary Prevention Study.
Eur Heart J. 2003 Oct;24(20):1833-42.
Nkeh
B, Samani NJ, Badenhorst D, Libhaber E, Sareli P, Norton GR,
Woodiwiss AJ.
T594M variant of the epithelial sodium channel beta-subunit
gene and hypertension in individuals of African ancestry in
South Africa. Am J Hypertens. 2003 Oct;16(10):847-52.
Moiseeva
EP, Williams B, Goodall AH, Samani NJ.
Galectin-1 interacts with beta-1 subunit of integrin.
Biochem Biophys Res Commun. 2003 Oct 24;310(3):1010-6.
Dorsch
MF, Barrett JA, Lawrance RA, Maqbool A, Durham NP, Ellis S,
Samani NJ, Bishop T, Ball SG, Balmforth AJ, Hall AS. Premature
coronary artery disease shows no evidence of linkage to loci
encoding for tissue inhibitors of matrix metalloproteinases.
J Hum Genet. 2003;48(10):508-13.
Caulfield
M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin
N, Webster J, Ratcliffe P, O'Shea S, Papp J, Taylor E, Dobson
R, Knight J, Newhouse S, Hooper J, Lee W, Brain N, Clayton D,
Lathrop GM, Farrall M, Connell J; MRC British Genetics of Hypertension
Study.
Genome-wide mapping of human loci for essential hypertension.
Lancet. 2003 Jun 21;361(9375):2118-23.
Walsh
V, Somody L, Farrell A, Zhang B, Brown J, Pritchard C, Vincent
M, Samani NJ.
Analysis
of the role of the SA gene in blood pressure regulation by gene
targeting.
Hypertension. 2003 Jun;41(6):1212-8.
Khunti
K, Samani NJ.
Improving the delivery of coronary care for ethnic minorities.
Heart. 2003 May;89(5):479-80.
Klimes
I, Weston K, Kovacs P, Gasperikova D, Jezova D, Kvetnansky R,
Thompson JR, Sebokova E, Samani NJ.
Mapping of genetic loci predisposing to hypertriglyceridaemia
in the hereditary hypertriglyceridaemic rat: analysis of genetic
association with related traits of the insulin resistance syndrome.
Diabetologia. 2003 Mar;46(3):352-8.
Brouilette
S, Singh RK, Thompson JR, Goodall AH, Samani NJ. White cell
telomere length and risk of premature myocardial infarction.
Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):842-6.
Samani
NJ.
Genome scans for hypertension and blood pressure regulation.
Am J Hypertens. 2003 Feb;16(2):167-71.
Moiseeva
EP, Williams B, Samani NJ.
Galectin 1 inhibits incorporation of vitronectin and chondroitin
sulfate B into the extracellular matrix of human vascular smooth
muscle cells.
Biochim Biophys Acta. 2003 Jan 20;1619(2):125-32.
Tiago
AD, Samani NJ, Candy GP, Brooksbank R, Libhaber EN, Sareli P,
Woodiwiss AJ, Norton GR.
Angiotensinogen gene promoter region variant modifies body size-ambulatory
blood pressure relations in hypertension.
Circulation. 2002 Sep 17;106(12):1483-7.
Clemitson
JR, Pratt JR, Frantz S, Sacks S, Samani NJ.
Kidney specificity of rat chromosome 1 blood pressure quantitative
trait locus region.
Hypertension. 2002 Sep;40(3):292-7.
Sensky
PR, Samani NJ, Reek C, Cherryman GR.
Magnetic resonance perfusion imaging in patients with coronary
artery disease: a qualitative approach.
Int J Cardiovasc Imaging. 2002 Oct;18(5):373-83; discussion
385-6.
Walton
TJ, Samani NJ, Andrews R.
Systemic cholesterol crystal embolisation with pulmonary involvement:
a fatal combination after coronary angiography. Postgrad Med
J. 2002 May;78(919):288-9.
Sensky
PR, Samani NJ, Horsfield MA, Cherryman GR.
Restoration of myocardial blood flow following percutaneous
coronary balloon dilatation and stent implantation: assessment
with qualitative and quantitative contrast-enhanced magnetic
resonance imaging.
Clin Radiol. 2002 Jul;57(7):593-9.
Gauguier
D, Samani N.
Approaches to the analysis of complex quantitative phenotypes
and marker map construction based on the analysis of rat models
of hypertension.
Methods Mol Biol. 2002;195:225-51.
Sensky
PR, Hudson NM, Keal RP, Samani NJ, Cherryman GR. Interpreting
regional myocardial magnetic resonance imaging data: a new method
for collation with angiographic findings in patients with coronary
artery disease.
Clin Radiol. 2002 Jun;57(6):498-501.
Singh
RK, McMahon AD, Patel H, Packard CJ, Rathbone BJ, Samani NJ.
Prospective analysis of the association of infection with CagA
bearing strains of Helicobacter pylori and coronary heart disease.
Heart. 2002 Jul;88(1):43-6.
Mahadeva
H, Brooks G, Lodwick D, Chong NW, Samani NJ.
ms1, a novel stress-responsive, muscle-specific gene that is
up-regulated in the early stages of pressure overload-induced
left ventricular hypertrophy.
FEBS Lett. 2002 Jun 19;521(1-3):100-4. Erratum in: FEBS Lett
2002 Sep 25;528(1-3):283.
Lo
M, Liu KL, Clemitson JR, Sassard J, Samani NJ.
Chromosome 1 blood pressure QTL region influences renal function
curve and salt sensitivity in SHR.
Physiol Genomics. 2002 Feb 11;8(1):15-21.
Samani
NJ.
Pharmacogenomics of hypertension: a realizable goal?
Clin Sci (Lond). 2000 Sep;99(3):231-2.
Di
Bitondo R, Cameron CL, Daly ME, Croft SA, Steeds RP, Channer
KS, Samani NJ, Lillicrap D, Winship PR.
The -1185 A/G and -1051 G/A dimorphisms in the von Willebrand
factor gene promoter and risk of myocardial infarction.
Br J Haematol. 2001 Dec;115(3):701-6.
Croft
SA, Samani NJ, Teare MD, Hampton KK, Steeds RP, Channer KS,
Daly ME.
Novel platelet membrane glycoprotein VI dimorphism is a risk
factor for myocardial infarction.
Circulation. 2001 Sep 25;104(13):1459-63.
Cullen
JH, Cherryman GR, Samani NJ, Tranter J, Jivan A, Horsfield MA,
Woods KL, Barnett DB.
Mechanism and clinical significance of precordial ST depression
in inferior myocardial infarction: evaluation by contrast-enhanced
dynamic myocardial perfusion magnetic resonance imaging.
J Cardiovasc Magn Reson. 1999;1(2):121-30.
Samani
NJ, Boultby R, Butler R, Thompson JR, Goodall AH. Telomere
shortening in atherosclerosis.
Lancet. 2001 Aug 11;358(9280):472-3.
Frantz
S, Clemitson JR, Bihoreau MT, Gauguier D, Samani NJ. Genetic
dissection of region around the Sa gene on rat chromosome 1:
evidence for multiple loci affecting blood pressure. Hypertension.
2001 Aug;38(2):216-21.
Croft
SA, Hampton KK, Daly ME, Steeds RP, Channer KS, Samani NJ.
Kozak sequence polymorphism in the platelet GPIbalpha gene is
not associated with risk of myocardial infarction.
Blood. 2000 Mar 15;95(6):2183-4.
Steeds
RP, Wardle A, Smith PD, Martin D, Channer KS, Samani NJ.
Analysis of the postulated interaction between the angiotensin
II sub-type 1 receptor gene A1166C polymorphism and the insertion/deletion
polymorphism of the angiotensin converting enzyme gene on risk
of myocardial infarction.
Atherosclerosis. 2001 Jan;154(1):123-8.
Salame
MY, Samani NJ, Masood I, deBono DP.
Expression of the plasminogen activator system in the human
vascular wall.
Atherosclerosis. 2000 Sep;152(1):19-28.
Azeem
T, Vassallo M, Samani NJ.
Images in cardiology. Endomyocardial fibrosis associated with
antiphospholipid syndrome.
Heart. 2000 Aug;84(2):156.
Gunn
M, Stephens JC, Thompson JR, Rathbone BJ, Samani NJ. Significant
association of cagA positive Helicobacter pylori strains with
risk of premature myocardial infarction.
Heart. 2000 Sep;84(3):267-71.
Barlassina
C, Norton GR, Samani NJ, Woodwiss AJ, Candy GC, Radevski I,
Citterio L, Bianchi G, Cusi D.
Alpha-adducin polymorphism in hypertensives of South African
ancestry.
Am J Hypertens. 2000 Jun;13(6 Pt 1):719-23.
Azeem
T, Vassallo M, Samani NJ.
Endomyocardial fibrosis associated with antiphospholipid syndrome
Heart. 2000 Aug;84(2):156.
Sensky
PR, Jivan A, Hudson NM, Keal RP, Morgan B, Tranter JL, de Bono
D, Samani NJ, Cherryman GR.
Coronary artery disease: combined stress MR imaging protocol-one-stop
evaluation of myocardial perfusion and function. Radiology.
2000 May;215(2):608-14.
Butler
R, Samani NJ.
Elective or selective use of abciximab?
Lancet. 2000 Feb 26;355(9205):755.
Patel
S, Steeds R, Channer K, Samani NJ.
Analysis of promoter region polymorphism in the aldosterone
synthase gene (CYP11B2) as a risk factor for myocardial infarction.
Am J Hypertens. 2000 Feb;13(2):134-9.
Candy
G, Samani N, Norton G, Woodiwiss A, Radevski I, Wheatley A,
Cockcroft J, Hall IP.
Association analysis of beta2 adrenoceptor polymorphisms with
hypertension in a Black African population.
J Hypertens. 2000 Feb;18(2):167-72.
Croft
SA, Hampton KK, Sorrell JA, Steeds RP, Channer KS, Samani NJ,
Daly ME.
The GPIa C807T dimorphism associated with platelet collagen
receptor density is not a risk factor for myocardial infarction.
Br J Haematol. 1999 Sep;106(3):771-6.
Croft
SA, Daly ME, Steeds RP, Channer KS, Samani NJ, Hampton KK.
The prothrombin 20210A allele and its association with myocardial
infarction.
Thromb Haemost. 1999 Jun;81(6):861-4.
Frantz
SA, Thiara AS, Lodwick D, Ng LL, Eperon IC, Samani NJ. Exon
repetition in mRNA.
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5400-5.
Cullen
JH, Horsfield MA, Reek CR, Cherryman GR, Barnett DB, Samani
NJ.
A myocardial perfusion reserve index in humans using first-pass
contrast-enhanced magnetic resonance imaging.
J Am Coll Cardiol. 1999 Apr;33(5):1386-94.
Mahadeva
H, Starkey MP, Sheikh FN, Mundy CR, Samani NJ.
A simple and efficient method for the isolation of differentially
expressed genes.
J Mol Biol. 1998 Dec 18;284(5):1391-8.
Samani
NJ.
Methylenetetrahydrofolate reductase mutation and coronary artery
disease.
Circulation. 1998 Dec 22-29;98(25):2932-3.
Samani
NJ.
Molecular genetics of coronary artery disease: measuring the
phenotype.
Clin Sci (Lond). 1998 Dec;95(6):645-6.
Frantz
SA, Kaiser M, Gardiner SM, Gauguier D, Vincent M, Thompson JR,
Bennett T, Samani NJ.
Successful isolation of a rat chromosome 1 blood pressure quantitative
trait locus in reciprocal congenic strains. Hypertension. 1998
Oct;32(4):639-46.
Kaiser
M, Kahr O, Shimada Y, Smith P, Kelly M, Mahadeva H, Adams M,
Lodwick D, Aalkjaer C, Avkiran M, Samani NJ.
Differential regulation of ventricular adrenomedullin and atrial
natriuretic peptide gene expression in pressure and volume overload
in the rat.
Clin Sci (Lond). 1998 Apr;94(4):359-65.
Steeds
R, Adams M, Smith P, Channer K, Samani NJ.
Distribution of tissue plasminogen activator insertion/deletion
polymorphism in myocardial infarction and control subjects.
Thromb Haemost. 1998 May;79(5):980-4.
Samani
NJ.
A positive parental history of high blood pressure.
J Hum Hypertens. 1998 Apr;12(4):209-10.
Lodwick
D, Zagato L, Kaiser MA, Torielli L, Casari G, Bianchi G, Samani
NJ.
Genetic
analysis of the SA and Na+/K+-ATPase alpha1 genes in the Milan
hypertensive rat.
J Hypertens. 1998 Feb;16(2):139-44.
Kovacs
P, Samani NJ, Sebokova E, Voigt B, Gasperikova D, Jezova D,
Kvetnansky R, Lodwick D, Kloting I, Klimes I.
Phenotype and genotype comparison of hereditary hypertriglyceridemic
(hHTG) and brown-Norway (BN) rats. Identification of quantitative
trait loci (QTLs) for the insulin resistance syndrome.
Ann N Y Acad Sci. 1997 Sep 20;827:526-31.
Vincent
M, Samani NJ, Gauguier D, Thompson JR, Lathrop GM, Sassard J.
A pharmacogenetic approach to blood pressure in Lyon hypertensive
rats. A chromosome 2 locus influences the response to a calcium
antagonist.
J Clin Invest. 1997 Oct 15;100(8):2000-6.
Kelly
MP, Kahr O, Aalkjaer C, Cumin F, Samani NJ.
Tissue expression of components of the renin-angiotensin system
in experimental post-infarction heart failure in rats: effects
of heart failure and angiotensin-converting enzyme inhibitor
treatment.
Clin Sci (Lond). 1997 May;92(5):455-65.
Bertaux
F, Colledge WH, Smith SE, Evans M, Samani NJ, Miller CC.
Normotensive blood pressure in mice with a disrupted renin Ren-1d
gene.
Transgenic Res. 1997 May;6(3):191-6.
Kaiser
M, Vincent M, Kenyon CJ, Gomez-Sanchez CE, Cumin F, Lodwick
D, Sassard J, Samani NJ.
Analysis of phenotypic consequences of renin gene polymorphism
in Lyon rats.
J Hypertens. 1997 Apr;15(4):365-72.
Samani
NJ, Lodwick D.
Glycoprotein IIIa polymorphism and risk of myocardial infarction.
Cardiovasc Res. 1997 Mar;33(3):693-7.
Samani
NJ, Gauguier D, Vincent M, Kaiser MA, Bihoreau MT, Lodwick D,
Wallis R, Parent V, Kimber P, Rattray F, Thompson JR, Sassard
J, Lathrop M.
Analysis of quantitative trait loci for blood pressure on rat
chromosomes 2 and 13. Age-related differences in effect. Hypertension.
1996 Dec;28(6):1118-22.
Hamet
P, Kaiser MA, Sun Y, Page V, Vincent M, Kren V, Pravenec M,
Kunes J, Tremblay J, Samani NJ.
HSP27 locus cosegregates with left ventricular mass independently
of blood pressure.
Hypertension. 1996 Dec;28(6):1112-7.
Frantz
SA, Thiara AS, Lodwick D, Samani NJ.
A major polymorphism in the rat SA gene caused by the insertion
of a LINE element.
Mamm Genome. 1996 Nov;7(11):865-6.
Rathbone
B, Martin D, Stephens J, Thompson JR, Samani NJ. Helicobacter
pylori seropositivity in subjects with acute myocardial infarction.
Heart. 1996 Oct;76(4):308-11
Samani
NJ, Martin DS, Brack M, Cullen J, Wallis R, Lodwick D, Chauhan
A, Harley A, Thompson JR, Gershlick AH, de Bono DP. Apolipoprotein
E polymorphism does not predict risk of restenosis after coronary
angioplasty.
Atherosclerosis. 1996 Sep 6;125(2):209-16.
Samani
NJ, Thompson JR, O'Toole L, Channer K, Woods KL.
A meta-analysis of the association of the deletion allele of
the angiotensin-converting enzyme gene with myocardial infarction.
Circulation. 1996 Aug 15;94(4):708-12.
Samani
NJ, O'Toole L, Martin D, Rai H, Fletcher S, Lodwick D, Thompson
JR, Morice AH, Channer K, Woods KL.
Insertion/deletion polymorphism in the angiotensin-converting
enzyme gene and risk of and prognosis after myocardial infarction.
J Am Coll Cardiol. 1996 Aug;28(2):338-44.
Adams
M, Smith PD, Martin D, Thompson JR, Lodwick D, Samani NJ.
Genetic analysis of thermolabile methylenetetrahydrofolate reductase
as a risk factor for myocardial infarction.
QJM. 1996 Jun;89(6):437-44.
Samani
NJ, de Bono DP.
Prevention
of coronary heart disease with pravastatin.
N Engl J Med. 1996 May 16;334(20):1333-4; author reply 1334-5.
Vincent
M, Cartier R, Privat P, Benzoni D, Samani NJ, Sassard J. Major
cardiovascular risk factors in Lyon hypertensive rats. A correlation
analysis in a segregating population.
J Hypertens. 1996 Apr;14(4):469-74.
Vincent
M, Hadour G, Orea V, Samani NJ, Sassard J.
Left ventricular weight but not blood pressure is associated
with sex chromosomes in Lyon rats.
J Hypertens. 1996 Mar;14(3):293-9.
de
Bono D, Gershlick AH, Samani NJ, Garratt CJ.
New training guidelines: what are the implications for cardiological
research?
Heart. 1996 Feb;75(2):118-20.
