MRC BRIGHT STUDY LOGO MRC Bright Study banner

Study Background

What is Hypertension?

Resource Information

Patient Resources

National DNA repository

Recruitment Procedures
Acknowledgements

Contact us

Genome Screen Results

Investigators

Nursing and Scientific Teams

Journal Club


start page     |    register     |    log-in    |    software

Dr John Webster (more to follow shortly)

Genome-wide association study identifies novel genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
Am J Hum Genet. 2008 Jan 10; 82(1) pp. 139 - 149
Chris Wallace; Stephen J Newhouse; Peter Braund; Feng Zhang; Martin Tobin; Mario Falchi; Kourosh Ahmadi; Richard J Dobson; Ana Carolina B Marçano; Cother Hajat; Paul Burton; Panagiotis Deloukas; Morris Brown; John M Connell; Anna Dominiczak; G Mark Lathrop; John Webster; The Wellcome Trust Case Control Consortium; Martin Farrall; Tim Spector; Nilesh J Samani; Mark J Caulfield; Patricia B. Munroe

Genomewide association analysis of coronary artery disease.
N Engl J Med. 2007 Aug 2;357(5):443-53. Epub 2007 Jul 18.
Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H, WTCCC

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
J Med Genet. 2007 Jun 8; [Epub ahead of print]
Braga Marcano AC, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D, Brown M, Dominiczak A, Connell JM, Webster J, Lathrop M, Caulfield M, Samani N, Gauguier D, Munroe PB.

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Nature. 2007 Jun 7;447(7145):661-78.
Wellcome Trust Case Control Consortium.

Chris Wallace, Ming-Zhan Xue, Stephen J. Newhouse, Ana Carolina B. Marçano, Abiodun K. Onipinla, Beverley Burke, Johannie Gungadoo, Richard J. Dobson, Morris Brown, John M. Connell, Anna Dominiczak, G. Mark Lathrop, John Webster, Martin Farrall, Charles Mein, Nilesh J. Samani, Mark J. Caulfield, David G. Clayton, and Patricia B. Munroe
Linkage Analysis Using Co-Phenotypes in the BRIGHT Study Reveals Novel Potential Susceptibility Loci for Hypertension.
Am J Hum Genet. 2006 Aug;79(2):323-31. Epub 2006 Jun 19.

Munroe PB, Wallace C, Xue MZ, B Marcano AC, Dobson RJ, Onipinla AK, Burke B, Gungadoo J, Newhouse SJ, Pembroke J, Brown M, Dominiczak AF, Samani NJ, Lathrop M, Connell J, Webster J, Clayton D, Farrall M, Mein CA, Caulfield M Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study.
Hypertension. 2006 Jun 5; [Epub ahead of print]


Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D, Samani N, Dominiczak A, Webster J, Lathrop GM, Connell J, Munroe P, Caulfield M, Farrall M.
Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension.
Hum Mol Genet. 2006 Apr 15;15(8):1365-74. Epub 2006 Mar 16

Sandosh Padmanabhan PhD, Chris Wallace Ph.D, Patricia B. Munroe Ph.D, Richard Dobson BSc, Morris Brown F.R.C.P, Nilesh Samani F.R.C.P, David Clayton B.A, Martin Farrall FRCPath, John Webster F.R.C.P, Mark Lathrop Ph.D, Mark Caulfield F.R.C.P, Anna F. Dominiczak F.R.C.P, John M. Connell F.R.C.P.
Chromosome 2p shows significant linkage to anti-hypertensive response in the British Genetics of Hypertension (BRIGHT) study.
Hypertension. 2006 Mar;47(3):603-8. Epub 2006 Jan 3.

S.J. Newhouse, C. Wallace, R. Dobson, C. Mein, J. Pembroke, M. Farrall, D. Clayton, M. Brown, N. Samani, A. Dominiczak, J.M. Connell, J. Webster, G.M. Lathrop, M. Caulfield, P. B. Munroe.
Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension (BRIGHT) study.
Human Molecular Genetics. Jul 1;14(13):1805-14. Epub 2005 May 11.

Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J, Ratcliffe P, O'Shea S, Papp J, Taylor E, Dobson R, Knight J, Newhouse S, Hooper J, Lee W, Brain N, Clayton D, Lathrop GM, Farrall M, Connell J; MRC British Genetics of Hypertension Study.
Genome-wide mapping of human loci for essential hypertension. Lancet. 2003 Jun 21;361(9375):2118-23.

 

 

 

MRC Bright Study small image

 



r.j.dobson@qmul.ac.uk
hi