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Professor Mark Caulfield (pubs from 1996)

Book chapters
C.A. Mein, M.J. Caulfield, P.B. Munroe.
Selection of candidate genes in hypertension.
In "Methods MolMed". 108: 107-130.

S.J. Newhouse, S. Huq, G. Arunachalam, M.J. Caulfield, P. B. Munroe.
Genetics of Hypertension.
In "Handbook of Hypertension: Principles and Practice" 4:47-65.

C. Wallace, M. Xue, M. Caulfield, P. B. Munroe.
Genome scans in Hypertension.
In "Handbook of Hypertension".
In press.

B. Burke, J. Gungadoo, A.C.B. Marçano, S.J. Newhouse, J. Shiel, M.J. Caulfield, P.B. Munroe.
Monogenic forms of hypertension.
In "Comprehensive Hypertension",
In press.

Review articles
A.C.B. Marcano, A.K. Onipinla, M. J. Caulfield, P.B. Munroe.
Recent advances in the identification of genes for human hypertension.
Expert Review of Cardiovascular Therapy. 2005 Jul;3(4):733-41.

Original articles
Genome-wide association study identifies novel genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
Am J Hum Genet. 2008 Jan 10; 82(1) pp. 139 - 149
Chris Wallace; Stephen J Newhouse; Peter Braund; Feng Zhang; Martin Tobin; Mario Falchi; Kourosh Ahmadi; Richard J Dobson; Ana Carolina B Marçano; Cother Hajat; Paul Burton; Panagiotis Deloukas; Morris Brown; John M Connell; Anna Dominiczak; G Mark Lathrop; John Webster; The Wellcome Trust Case Control Consortium; Martin Farrall; Tim Spector; Nilesh J Samani; Mark J Caulfield; Patricia B. Munroe

Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates.
Genome Res. 2007 Sep 25; [Epub ahead of print]
Wallace C, Dobson RJ, Munroe PB, Caulfield MJ.

Genomewide association analysis of coronary artery disease.
N Engl J Med. 2007 Aug 2;357(5):443-53. Epub 2007 Jul 18.
Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H, WTCCC

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
J Med Genet. 2007 Jun 8; [Epub ahead of print]
Braga Marcano AC, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D, Brown M, Dominiczak A, Connell JM, Webster J, Lathrop M, Caulfield M, Samani N, Gauguier D, Munroe PB.

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Nature. 2007 Jun 7;447(7145):661-78.
Wellcome Trust Case Control Consortium.

Chris Wallace, Ming-Zhan Xue, Stephen J. Newhouse, Ana Carolina B. Marçano, Abiodun K. Onipinla, Beverley Burke, Johannie Gungadoo, Richard J. Dobson, Morris Brown, John M. Connell, Anna Dominiczak, G. Mark Lathrop, John Webster, Martin Farrall, Charles Mein, Nilesh J. Samani, Mark J. Caulfield, David G. Clayton, and Patricia B. Munroe
Linkage Analysis Using Co-Phenotypes in the BRIGHT Study Reveals Novel Potential Susceptibility Loci for Hypertension.
Am J Hum Genet. 2006 Aug;79(2):323-31. Epub 2006 Jun 19.

Munroe PB, Wallace C, Xue MZ, B Marcano AC, Dobson RJ, Onipinla AK, Burke B, Gungadoo J, Newhouse SJ, Pembroke J, Brown M, Dominiczak AF, Samani NJ, Lathrop M, Connell J, Webster J, Clayton D, Farrall M, Mein CA, Caulfield M Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study.
Hypertension. 2006 Jun 5; [Epub ahead of print]

RJ Dobson, PB Munroe, MJ Caulfield, MAS Saqi.
Predicting deleterious nsSNPs: an analysis of sequence and structural attributes.
BMC Bioinformatics, 2006 Apr 21;7(1):217 [Epub ahead of print].

Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D, Samani N, Dominiczak A, Webster J, Lathrop GM, Connell J, Munroe P, Caulfield M, Farrall M.
Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension.
Hum Mol Genet. 2006 Apr 15;15(8):1365-74. Epub 2006 Mar 16

Binder A, Garcia E, Wallace C, Gbenga K, Ben-Shlomo Y, Yarnell J, Brown P, Caulfield M, Skrabal F, Kotanko P, Munroe P.
Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study.
J Hypertens. 2006 Mar;24(3):471-477.

Sandosh Padmanabhan PhD, Chris Wallace Ph.D, Patricia B. Munroe Ph.D, Richard Dobson BSc, Morris Brown F.R.C.P, Nilesh Samani F.R.C.P, David Clayton B.A, Martin Farrall FRCPath, John Webster F.R.C.P, Mark Lathrop Ph.D, Mark Caulfield F.R.C.P, Anna F. Dominiczak F.R.C.P, John M. Connell F.R.C.P.
Chromosome 2p shows significant linkage to anti-hypertensive response in the British Genetics of Hypertension (BRIGHT) study.
Hypertension. 2006 Mar;47(3):603-8. Epub 2006 Jan 3.

M.D.Tobin, S. M. Raleigh, S. Newhouse, P. Braund, C. Bodycote, J. Ogleby, D. Cross, S. Hayes, T. Smith, J. Gracey, C. Ridge, M. Caulfield, P. B. Munroe, P. R. Burton, N. J. Samani.
Association of PRKWNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population.
Circulation. 2005 Nov 29;112(22):3423-9. Epub 2005 Nov 21.

S.J. Newhouse, C. Wallace, R. Dobson, C. Mein, J. Pembroke, M. Farrall, D. Clayton, M. Brown, N. Samani, A. Dominiczak, J.M. Connell, J. Webster, G.M. Lathrop, M. Caulfield, P. B. Munroe.
Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension (BRIGHT) study.
Human Molecular Genetics. Jul 1;14(13):1805-14. Epub 2005 May 11.

Recent advances in the identification of genes for human hypertension.
Expert Rev Cardiovasc Ther. 2005 Jul;3(4):733-41.
Marcano AC, Onipinla AK, Caulfield MJ, Munroe PB.

Genetics of essential hypertension. Hum Mol Genet. 2004 Apr 1;13 Suppl 1:R169-75. Epub 2004 Feb 05.
Mein CA, Caulfield MJ, Dobson RJ, Munroe PB.

Genes and hypertension.
Curr Pharm Des. 2003;9(21):1679-89. Review.
Garcia EA, Newhouse S, Caulfield MJ, Munroe PB.

Genome-wide mapping of human loci for essential hypertension. Lancet. 2003 Jun 21;361(9375):2118-23.
Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J, Ratcliffe P, O'Shea S, Papp J, Taylor E, Dobson R, Knight J, Newhouse S, Hooper J, Lee W, Brain N, Clayton D, Lathrop GM, Farrall M, Connell J; MRC British Genetics of Hypertension Study.

Comparison of methods to identify individuals at increased risk of coronary disease from the general population.
BMJ. 2003 Jun 28;326(7404):1436.
Wilson S, Johnston A, Robson J, Poulter N, Collier D, Feder G, Caulfield MJ.

Human chromosome 17 in essential hypertension.
Ann Hum Genet. 2003 Mar;67(Pt 2):193-206. Review.
Knight J, Munroe PB, Pembroke JC, Caulfield MJ.

Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial.
Lancet. 2003 Apr 5;361(9364):1149-58.
Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J; ASCOT investigators.

Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol?
J Cardiovasc Risk. 2003 Apr;10(2):137-41.
Wilson S, Johnston A, Robson J, Poulter NR, Collier DJ, Feder GS, Caulfield MJ.

Baroreflex sensitivity and heart rate variability as predictors of cardiovascular outcome in hypertensive patients with multiple risk factors for coronary disease.
J Hum Hypertens. 2001 Aug;15 Suppl 1:S57-60.
Collier DJ, Bernardi L, Angell-James JE, Caulfield MJ, Sleight P; Anglo-Scandinavian Cardiac Outcomes Trial.

Ethnic variations in response to a statin (EVIREST).
J Hum Hypertens. 2001 Aug;15 Suppl 1:S87-9.
Poulter NR, Caulfield M, Feder G; Anglo-Scandinavian Cardiac Outcomes Trial.

Differential response to amlodipine and atenolol mono-therapy for hypertension by ethnic group.
J Hum Hypertens. 2001 Aug;15 Suppl 1:S61-4.
Kirby PL, Caulfield MC, Collier DJ, Eldridge S, Griffiths CG, Hemingway H, Poulter NR, Feder GS; Anglo-Scandinavian Cardiac Outcomes Trial.

Ambulatory blood pressure monitoring and 24-h blood pressure control as predictors of outcome in treated hypertensive patients. J Hum Hypertens. 2001 Aug;15 Suppl 1:S47-51.
O'Brien E, McInnes GT, Stanton A, Thom S, Caulfield M, Atkins N, Nichol FM; Anglo-Scandinavian Cardiac Outcomes Trial.

Evaluation of cardiovascular risk equations using the ASCOT cohort.
J Hum Hypertens. 2001 Aug;15 Suppl 1:S31-3.
Wilson S, Collier D, Johnston A, Poulter N, Feder G, Robson J, Caulfield M; Anglo-Scandinavian Cardiac Outcomes Trial.

Cardiovascular risk factors in a cohort of 30,000 high-risk men and women in the UK: cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).
J Hum Hypertens. 2001 Aug;15 Suppl 1:S23-6.
Chapman JN, Kirby P, Caulfield MC, Poulter NR; Anglo-Scandinavian Cardiac Outcomes Trial.

Anglo-Scandinavian Cardiac Outcomes Trial: a brief history, rationale and outline protocol.
J Hum Hypertens. 2001 Aug;15 Suppl 1:S11-2.
Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J; ASCOT Steering Committee, Anglo-Scandinavian Cardiac Outcomes Trial.

Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11beta-hydroxysteroid dehydrogenase to hypertension in Black people.
Clin Endocrinol (Oxf). 2001 Aug;55(2):249-52.
White PC, Agarwal AK, Li A, Nikkila H, Pratt JH, Caulfield M, Clark A, McTernan C, Stewart PM.

Pseudoexon activation as a novel mechanism for disease resulting in atypical growth-hormone insensitivity.
Am J Hum Genet. 2001 Sep;69(3):641-6. Epub 2001 Jul 20.
Metherell LA, Akker SA, Munroe PB, Rose SJ, Caulfield M, Savage MO, Chew SL, Clark AJ.

Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian Cardiac Outcomes Trial. ASCOT investigators. J Hypertens. 2001 Jun;19(6):1139-47.
Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J.

Genes for common diseases.
Br J Clin Pharmacol. 2001 Jan;51(1):1-3
Caulfield MJ.

1990-2000: progress in determining high blood pressure genes.
Ann Acad Med Singapore. 2000 May;29(3):357-63. Review.
Munroe PB, Knight J, Caulfield MJ.

Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans. J Hum Hypertens. 2000 Jun;14(6):385-7.
Knight J, Gardner GT, Clark AJ, Caulfield MJ.

Genetics of hypertension.
Curr Opin Genet Dev. 2000 Jun;10(3):325-9. Review. of Clinical Pharmacology
Munroe PB, Caulfield MJ.

Genetics of hypertension.
Therapeutic implications. Drugs. 1998 Aug;56(2):203-14. Review.
O'Byrne S, Caulfield M.

Absence of linkage of the epithelial sodium channel to hypertension in black Caribbeans.
Am J Hypertens. 1998 Aug;11(8 Pt 1):942-5.
Munroe PB, Strautnieks SS, Farrall M, Daniel HI, Lawson M, DeFreitas P, Fogarty P, Gardiner RM, Caulfield M.

Evaluation of the angiotensinogen locus in human essential hypertension: a European study.
Hypertension. 1998 Mar;31(3):725-9.
Brand E, Chatelain N, Keavney B, Caulfield M, Citterio L, Connell J, Grobbee D, Schmidt S, Schunkert H, Schuster H, Sharma AM, Soubrier F.

The genetic basis of hypertension: progress and opportunities.
Hosp Med. 1998 Jan;59(1):37-40. Review.
Caulfield M, Collier D, O'Byrne S.

Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor. Hypertension. 1997 Oct;30(4):773-6.
Kotanko P, Binder A, Tasker J, DeFreitas P, Kamdar S, Clark AJ, Skrabal F, Caulfield M.

Progress in determining the genes for hypertension, insulin resistance, and dyslipidemia.
Ann N Y Acad Sci. 1997 Sep 20;827:110-7. Review.
Caulfield M, Bouloux PM, Munroe P.

The atrial natriuretic peptide gene and essential hypertension in African-Caribbeans from St Vincent and the Grenadines.
J Hum Hypertens. 1997 Feb;11(2):113-7.
Daniel HI, Munroe PB, Kamdar SM, Lawson M, Lavender P, Forgaty P, Caulfield MJ.

Angiotensinogen in human essential hypertension.
Hypertension. 1996 Dec;28(6):1123-5. Review.
Caulfield M, Lavender P, Newell-Price J, Kamdar S, Farrall M, Clark AJ.



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