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Mr David Clayton (pubs from 1996)

Genome-wide association study identifies novel genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
Am J Hum Genet. 2008 Jan 10; 82(1) pp. 139 - 149
Chris Wallace; Stephen J Newhouse; Peter Braund; Feng Zhang; Martin Tobin; Mario Falchi; Kourosh Ahmadi; Richard J Dobson; Ana Carolina B Marçano; Cother Hajat; Paul Burton; Panagiotis Deloukas; Morris Brown; John M Connell; Anna Dominiczak; G Mark Lathrop; John Webster; The Wellcome Trust Case Control Consortium; Martin Farrall; Tim Spector; Nilesh J Samani; Mark J Caulfield; Patricia B. Munroe

Genomewide association analysis of coronary artery disease.
N Engl J Med. 2007 Aug 2;357(5):443-53. Epub 2007 Jul 18.
Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H, WTCCC

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
J Med Genet. 2007 Jun 8; [Epub ahead of print]
Braga Marcano AC, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D, Brown M, Dominiczak A, Connell JM, Webster J, Lathrop M, Caulfield M, Samani N, Gauguier D, Munroe PB.

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Nature. 2007 Jun 7;447(7145):661-78.
Wellcome Trust Case Control Consortium.

Chris Wallace, Ming-Zhan Xue, Stephen J. Newhouse, Ana Carolina B. Marçano, Abiodun K. Onipinla, Beverley Burke, Johannie Gungadoo, Richard J. Dobson, Morris Brown, John M. Connell, Anna Dominiczak, G. Mark Lathrop, John Webster, Martin Farrall, Charles Mein, Nilesh J. Samani, Mark J. Caulfield, David G. Clayton, and Patricia B. Munroe
Linkage Analysis Using Co-Phenotypes in the BRIGHT Study Reveals Novel Potential Susceptibility Loci for Hypertension.
Am J Hum Genet. 2006 Aug;79(2):323-31. Epub 2006 Jun 19.

Munroe PB, Wallace C, Xue MZ, B Marcano AC, Dobson RJ, Onipinla AK, Burke B, Gungadoo J, Newhouse SJ, Pembroke J, Brown M, Dominiczak AF, Samani NJ, Lathrop M, Connell J, Webster J, Clayton D, Farrall M, Mein CA, Caulfield M Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study.
Hypertension. 2006 Jun 5; [Epub ahead of print]

Wallace, C. & Clayton, D.G.
Appropriate Use of Information on Family History of Disease in Recruitment for Linkage Analysis Studies.
Annals of Human Genetics (in press).

Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D, Samani N, Dominiczak A, Webster J, Lathrop GM, Connell J, Munroe P, Caulfield M, Farrall M.
Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension.
Hum Mol Genet. 2006 Apr 15;15(8):1365-74. Epub 2006 Mar 16

Wallace C, Chapman JM, Clayton DG.
Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait Loci by selective genotyping.
Am J Hum Genet. 2006 Mar;78(3):498-504. Epub 2006 Jan 5.

Sandosh Padmanabhan PhD, Chris Wallace Ph.D, Patricia B. Munroe Ph.D, Richard Dobson BSc, Morris Brown F.R.C.P, Nilesh Samani F.R.C.P, David Clayton B.A, Martin Farrall FRCPath, John Webster F.R.C.P, Mark Lathrop Ph.D, Mark Caulfield F.R.C.P, Anna F. Dominiczak F.R.C.P, John M. Connell F.R.C.P.
Chromosome 2p shows significant linkage to anti-hypertensive response in the British Genetics of Hypertension (BRIGHT) study.
Hypertension. 2006 Mar;47(3):603-8. Epub 2006 Jan 3.

S.J. Newhouse, C. Wallace, R. Dobson, C. Mein, J. Pembroke, M. Farrall, D. Clayton, M. Brown, N. Samani, A. Dominiczak, J.M. Connell, J. Webster, G.M. Lathrop, M. Caulfield, P. B. Munroe.
Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension (BRIGHT) study.
Human Molecular Genetics. Jul 1;14(13):1805-14. Epub 2005 May 11.

Lowe CE, Cooper JD, Chapman JM, Barratt BJ, Twells RC, Green EA, Savage DA, Guja C, Ionescu-Tirgoviste C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA, Clayton DG.
Cost-effective analysis of candidate genes using htSNPs: a staged approach.
Genes Immun. 2004 Mar 18

Thomas DC, Clayton DG.
Betting odds and genetic associations.
J Natl Cancer Inst. 2004 Mar 17;96(6):421-3. Review.

Cordell HJ, Barratt BJ, Clayton DG.
Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects.
Genet Epidemiol. 2004 Apr;26(3):167-85.

Wallace C, Fitness J, Hennig B, Sichali L, Mwaungulu L, Ponnighaus JM, Warndorff DK, Clayton D, Fine PE, Hill AV. Linkage analysis of susceptibility to leprosy type using an IBD regression method.
Genes Immun. 2004 Mar 11

Cordell HJ, Howson JM, Clayton DG.
Linkage analysis of a derived glucose phenotype in the Genetic Analysis Workshop 13 simulated data using a variety of Haseman-Elston based regression methods.
BMC Genet. 2003 Dec 31;4 Suppl 1:S6. PMID: 14975074

Wallace C, Clayton D.
Estimating the relative recurrence risk ratio using a global cross-ratio model.
Genet Epidemiol. 2003 Dec;25(4):293-302.

Chapman JM, Cooper JD, Todd JA, Clayton DG.
Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power.
Hum Hered. 2003;56(1-3):18-31.

Barroso I, Luan J, Middelberg RP, Harding AH, Franks PW, Jakes RW, Clayton D, Schafer AJ, O'Rahilly S, Wareham NJ.
Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in beta-Cell Function as Well as Insulin Action.
PLoS Biol. 2003 Oct;1(1):E20. Epub 2003 Oct 13.

Maier LM, Twells RC, Howson JM, Lam AC, Clayton DG, Smyth DJ, Savage D, Carson D, Patterson CC, Smink LJ, Walker NM, Burren OS, Nutland S, Rance H, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Cucca F, Todd JA.
Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene. Genes Immun. 2003 Oct;4(7):469-75.

Wallace C, Clayton D, Fine P.
Estimating the relative recurrence risk ratio for leprosy in Karonga District, Malawi.
Lepr Rev. 2003 Jun;74(2):133-40.

Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J, Ratcliffe P, O'Shea S, Papp J, Taylor E, Dobson R, Knight J, Newhouse S, Hooper J, Lee W, Brain N, Clayton D, Lathrop GM, Farrall M, Connell J; MRC British Genetics of Hypertension Study.
Genome-wide mapping of human loci for essential hypertension. Lancet. 2003 Jun 21;361(9375):2118-23.

Hoggart CJ, Parra EJ, Shriver MD, Bonilla C, Kittles RA, Clayton DG, McKeigue PM.
Control of confounding of genetic associations in stratified populations.
Am J Hum Genet. 2003 Jun;72(6):1492-1504.

Twells RC, Mein CA, Phillips MS, Hess JF, Veijola R, Gilbey M, Bright M, Metzker M, Lie BA, Kingsnorth A, Gregory E, Nakagawa Y, Snook H, Wang WY, Masters J, Johnson G, Eaves I, Howson JM, Clayton D, Cordell HJ, Nutland S, Rance H, Carr P, Todd JA. Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene.
Genome Res. 2003 May;13(5):845-55.

Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC.
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
Nature. 2003 May 29;423(6939):506-11.

Barratt BJ, Payne F, Rance HE, Nutland S, Todd JA, Clayton DG. Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design.
Ann Hum Genet. 2002 Nov;66(Pt 5-6):393-405.

Sawcer S, Maranian M, Setakis E, Curwen V, Akesson E, Hensiek A, Coraddu F, Roxburgh R, Sawcer D, Gray J, Deans J, Goodfellow PN, Walker N, Clayton D, Compston A.
A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility.
Brain. 2002 Jun;125(Pt 6):1337-47.

Thomas DC, Morrison JL, Clayton DG.
Bayes estimates of haplotype effects.
Genet Epidemiol. 2001;21 Suppl 1:S712-7.

Chataway J, Mander A, Robertson N, Sawcer S, Deans J, Fraser M, Broadley S, Clayton D, Compston A.
Multiple sclerosis in sibling pairs: an analysis of 250 families.
J Neurol Neurosurg Psychiatry. 2001 Dec;71(6):757-61.

Cordell HJ, Clayton DG.
A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes.
Am J Hum Genet. 2002 Jan;70(1):124-41.

Clayton D, McKeigue PM.
Epidemiological methods for studying genes and environmental factors in complex diseases.
Lancet. 2001 Oct 20;358(9290):1356-60. Review.

Johnson GC, Esposito L, Barratt BJ, Smith AN, Heward J, Di Genova G, Ueda H, Cordell HJ, Eaves IA, Dudbridge F, Twells RC, Payne F, Hughes W, Nutland S, Stevens H, Carr P, Tuomilehto-Wolf E, Tuomilehto J, Gough SC, Clayton DG, Todd JA.
Haplotype tagging for the identification of common disease genes. Nat Genet. 2001 Oct;29(2):233-7.

Broadley S, Sawcer S, D'Alfonso S, Hensiek A, Coraddu F, Gray J, Roxburgh R, Clayton D, Buttinelli C, Quattrone A, Trojano M, Massacesi L, Compston A.
A genome screen for multiple sclerosis in Italian families.
Genes Immun. 2001 Jun;2(4):205-10.

Hupperts R, Broadley S, Mander A, Clayton D, Compston DA, Robertson NP.
Patterns of disease in concordant parent-child pairs with multiple sclerosis.
Neurology. 2001 Jul 24;57(2):290-5.

Broadley SA, Sawcer SJ, Chataway SJ, Coraddu F, Coles A, Gray J, Roxburgh R, Clayton D, Compston DA.
No association between multiple sclerosis and the Notch3 gene responsible for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
J Neurol Neurosurg Psychiatry. 2001 Jul;71(1):97-9.

Khan N, Graham E, Dixon P, Morris C, Mander A, Clayton D, Vaughan J, Quinn N, Lees A, Daniel S, Wood N, de Silva R. Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype.
Ann Neurol. 2001 May;49(5):665-8.

Cordell HJ, Todd JA, Hill NJ, Lord CJ, Lyons PA, Peterson LB, Wicker LS, Clayton DG.
Statistical modeling of interlocus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes. Genetics. 2001 May;158(1):357-67.

Bitti PP, Murgia BS, Ticca A, Ferrai R, Musu L, Piras ML, Puledda E, Campo S, Durando S, Montomoli C, Clayton DG, Mander AP, Bernardinelli L.
Association between the ancestral haplotype HLA A30B18DR3 and multiple sclerosis in central Sardinia.
Genet Epidemiol. 2001 Feb;20(2):271-83.

Chataway J, Sawcer S, Coraddu F, Feakes R, Broadley S, Jones HB, Clayton D, Gray J, Goodfellow PN, Compston A.
Evidence that allelic variants of the spinocerebellar ataxia type 2 gene influence susceptibility to multiple sclerosis.
Neurogenetics. 1999 Apr;2(2):91-6.

Ecochard R, Clayton DG.
Multivariate parametric random effect regression models for fecundability studies.
Biometrics. 2000 Dec;56(4):1023-9.

Clarke JR, Jenkins MA, Hopper JL, Carlin JB, Mayne C, Clayton DG, Dalton MF, Holst DP, Robertson CF.
Evidence for genetic associations between asthma, atopy, and bronchial hyperresponsiveness: a study of 8- to 18-yr-old twins. Am J Respir Crit Care Med. 2000 Dec;162(6):2188-93.

Sanjeevi CB, Miller EN, Dabadghao P, Rumba I, Shtauvere A, Denisova A, Clayton D, Blackwell JM.
Polymorphism at NRAMP1 and D2S1471 loci associated with juvenile rheumatoid arthritis.
Arthritis Rheum. 2000 Jun;43(6):1397-404.

Sharma P, Fatibene J, Ferraro F, Jia H, Monteith S, Brown C, Clayton D, O'Shaughnessy K, Brown MJ.
A genome-wide search for susceptibility loci to human essential hypertension.
Hypertension. 2000 Jun;35(6):1291-6.

Dudbridge F, Koeleman BP, Todd JA, Clayton DG.
Unbiased application of the transmission/disequilibrium test to multilocus haplotypes.
Am J Hum Genet. 2000 Jun;66(6):2009-12.

Feakes R, Sawcer S, Broadley S, Coraddu F, Roxburgh R, Gray J, Clayton D, Compston A.
Interleukin 1 receptor antagonist (IL-1ra) in multiple sclerosis.
J Neuroimmunol. 2000 Jun 1;105(1):96-101.

Chataway J, Sawcer S, Sherman D, Hobart M, Fernie B, Coraddu F, Feakes R, Broadley S, Gray J, Jones HB, Clayton D, Goodfellow PN, Compston A.
No evidence for association of multiple sclerosis with the complement factors C6 and C7.
J Neuroimmunol. 1999 Sep 1;99(1):150-6.

Clayton D.
A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission.
Am J Hum Genet. 1999 Oct;65(4):1170-7.

Clayton D, Jones H.
Transmission/disequilibrium tests for extended marker haplotypes. Am J Hum Genet. 1999 Oct;65(4):1161-9.

Chataway J, Sawcer S, Feakes R, Coraddu F, Broadley S, Jones HB, Clayton D, Gray J, Goodfellow PN, Compston A.
A screen of candidates from peaks of linkage: evidence for the involvement of myeloperoxidase in multiple sclerosis.
J Neuroimmunol. 1999 Aug 3;98(2):208-13.

Coraddu F, Sawcer S, Feakes R, Chataway J, Broadley S, Jones HB, Clayton D, Gray J, Smith S, Taylor C, Goodfellow PN, Compston A.
HLA typing in the United Kingdom multiple sclerosis genome screen.
Neurogenetics. 1998 Dec;2(1):24-33.

Feakes R, Sawcer S, Chataway J, Coraddu F, Broadley S, Gray J, Jones HB, Clayton D, Goodfellow PN, Compston A.
Exploring the dense mapping of a region of potential linkage in complex disease: an example in multiple sclerosis.
Genet Epidemiol. 1999;17(1):51-63.

Lewis I, Lachmeijer G, Downing S, Dekker G, Glazebrook C, Clayton D, Morris NH, O'Shaughnessy KM.
Failure to detect linkage of preeclampsia to the region of the NOS3 locus on chromosome 7q.
Am J Hum Genet. 1999 Jan;64(1):310-3.

Feakes R, Chataway J, Sawcer S, Jones HB, Clayton D, Goodfellow PN, Compston A.
Susceptibility to multiple sclerosis and the immunoglobulin heavy chain gene cluster.
Ann Neurol. 1998 Dec;44(6):984.

Chataway J, Feakes R, Coraddu F, Gray J, Deans J, Fraser M, Robertson N, Broadley S, Jones H, Clayton D, Goodfellow P, Sawcer S, Compston A.
The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen. Brain. 1998 Oct;121 ( Pt 10):1869-87

Sharma P, Hingorani A, Jia H, Ashby M, Hopper R, Clayton D, Brown MJ.
Positive association of tyrosine hydroxylase microsatellite marker to essential hypertension.
Hypertension. 1998 Oct;32(4):676-82.

Chiano MN, Clayton DG.
Fine genetic mapping using haplotype analysis and the missing data problem.
Ann Hum Genet. 1998 Jan;62 ( Pt 1):55-60.

Ecochard R, Clayton DG.
Multi-level modelling of conception in artificial insemination by donor.
Stat Med. 1998 May 30;17(10):1137-56.

Chiano MN, Clayton DG.
Genotypic relative risks under ordered restriction.
Genet Epidemiol. 1998;15(2):135-46

Moreau T, Coles A, Wing M, Thorpe J, Miller D, Moseley I, Issacs J, Hale G, Clayton D, Scolding N, Waldmann H, Compston A. CAMPATH-IH in multiple sclerosis.
Mult Scler. 1996 Jul;1(6):357-65.

Robertson NP, O'Riordan JI, Chataway J, Kingsley DP, Miller DH, Clayton D, Compston DA.
Offspring recurrence rates and clinical characteristics of conjugal multiple sclerosis.
Lancet. 1997 May 31;349(9065):1587-90.

Dunning AM, Chiano M, Smith NR, Dearden J, Gore M, Oakes S, Wilson C, Stratton M, Peto J, Easton D, Clayton D, Ponder BA. Common BRCA1 variants and susceptibility to breast and ovarian cancer in the general population.
Hum Mol Genet. 1997 Feb;6(2):285-9.

Sawcer S, Jones HB, Judge D, Visser F, Compston A, Goodfellow PN, Clayton D.
Empirical genomewide significance levels established by whole genome simulations. Genet Epidemiol. 1997;14(3):223-9.

Shaw MA, Clayton D, Blackwell JM.
Analysis of the candidate gene NRAMP1 in the first 61 ARC National Repository families for rheumatoid arthritis.
J Rheumatol. 1997 Jan;24(1):212-4.

Eng C, Clayton D, Schuffenecker I, Lenoir G, Cote G, Gagel RF, van Amstel HK, Lips CJ, Nishisho I, Takai SI, Marsh DJ, Robinson BG, Frank-Raue K, Raue F, Xue F, Noll WW, Romei C, Pacini F, Fink M, Niederle B, Zedenius J, Nordenskjold M, Komminoth P, Hendy GN, Mulligan LM, et al.
The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. JAMA. 1996 Nov 20;276(19):1575-9.

Shaw MA, Clayton D, Atkinson SE, Williams H, Miller N, Sibthorpe D, Blackwell JM.
Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35. J Med Genet. 1996 Aug;33(8):672-7

Robertson NP, Clayton D, Fraser M, Deans J, Compston DA. Clinical concordance in sibling pairs with multiple sclerosis. Neurology. 1996 Aug;47(2):347-52.

Sawcer S, Jones HB, Feakes R, Gray J, Smaldon N, Chataway J, Robertson N, Clayton D, Goodfellow PN, Compston A.
A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22.
Nat Genet. 1996 Aug;13(4):464-8.

Robertson NP, Fraser M, Deans J, Clayton D, Walker N, Compston DA.
Age-adjusted recurrence risks for relatives of patients with multiple sclerosis.
Brain. 1996 Apr;119 ( Pt 2):449-55.












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