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Prof John Connell (pubs from 2000)

Genome-wide association study identifies novel genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
Am J Hum Genet. 2008 Jan 10; 82(1) pp. 139 - 149
Chris Wallace; Stephen J Newhouse; Peter Braund; Feng Zhang; Martin Tobin; Mario Falchi; Kourosh Ahmadi; Richard J Dobson; Ana Carolina B Marçano; Cother Hajat; Paul Burton; Panagiotis Deloukas; Morris Brown; John M Connell; Anna Dominiczak; G Mark Lathrop; John Webster; The Wellcome Trust Case Control Consortium; Martin Farrall; Tim Spector; Nilesh J Samani; Mark J Caulfield; Patricia B. Munroe

Genomewide association analysis of coronary artery disease.
N Engl J Med. 2007 Aug 2;357(5):443-53. Epub 2007 Jul 18.
Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H, WTCCC

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
J Med Genet. 2007 Jun 8; [Epub ahead of print]
Braga Marcano AC, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D, Brown M, Dominiczak A, Connell JM, Webster J, Lathrop M, Caulfield M, Samani N, Gauguier D, Munroe PB.

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Nature. 2007 Jun 7;447(7145):661-78.
Wellcome Trust Case Control Consortium.

Chris Wallace, Ming-Zhan Xue, Stephen J. Newhouse, Ana Carolina B. Marçano, Abiodun K. Onipinla, Beverley Burke, Johannie Gungadoo, Richard J. Dobson, Morris Brown, John M. Connell, Anna Dominiczak, G. Mark Lathrop, John Webster, Martin Farrall, Charles Mein, Nilesh J. Samani, Mark J. Caulfield, David G. Clayton, and Patricia B. Munroe
Linkage Analysis Using Co-Phenotypes in the BRIGHT Study Reveals Novel Potential Susceptibility Loci for Hypertension.
Am J Hum Genet. 2006 Aug;79(2):323-31. Epub 2006 Jun 19.

Munroe PB, Wallace C, Xue MZ, B Marcano AC, Dobson RJ, Onipinla AK, Burke B, Gungadoo J, Newhouse SJ, Pembroke J, Brown M, Dominiczak AF, Samani NJ, Lathrop M, Connell J, Webster J, Clayton D, Farrall M, Mein CA, Caulfield M Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study.
Hypertension. 2006 Jun 5; [Epub ahead of print]

Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D, Samani N, Dominiczak A, Webster J, Lathrop GM, Connell J, Munroe P, Caulfield M, Farrall M.
Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension.
Hum Mol Genet. 2006 Apr 15;15(8):1365-74. Epub 2006 Mar 16

Sandosh Padmanabhan PhD, Chris Wallace Ph.D, Patricia B. Munroe Ph.D, Richard Dobson BSc, Morris Brown F.R.C.P, Nilesh Samani F.R.C.P, David Clayton B.A, Martin Farrall FRCPath, John Webster F.R.C.P, Mark Lathrop Ph.D, Mark Caulfield F.R.C.P, Anna F. Dominiczak F.R.C.P, John M. Connell F.R.C.P.
Chromosome 2p shows significant linkage to anti-hypertensive response in the British Genetics of Hypertension (BRIGHT) study.
Hypertension. 2006 Mar;47(3):603-8. Epub 2006 Jan 3.

S.J. Newhouse, C. Wallace, R. Dobson, C. Mein, J. Pembroke, M. Farrall, D. Clayton, M. Brown, N. Samani, A. Dominiczak, J.M. Connell, J. Webster, G.M. Lathrop, M. Caulfield, P. B. Munroe.
Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension (BRIGHT) study.
Human Molecular Genetics. Jul 1;14(13):1805-14. Epub 2005 May 11.

James DJ, Salaun C, Brandie FM, Connell JM, Chamberlain LH. Neomycin prevents the wortmannin-inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes. J Biol Chem. 2004

McEleavy OD, McCallum RW, Petrie JR, Small M, Connell JM, Sattar N, Cleland SJ.
Higher carotid-radial pulse wave velocity in healthy offspring of patients with Type 2 diabetes.
Diabet Med. 2004 Mar;21(3):262-6.

Perry CG, Spiers A, Cleland SJ, Lowe GD, Petrie JR, Connell JM. Glucocorticoids and insulin sensitivity: dissociation of insulin's metabolic and vascular actions.
J Clin Endocrinol Metab. 2003 Dec;88(12):6008-14.

Ye P, Kenyon CJ, MacKenzie SM, Seckl JR, Fraser R, Connell JM, Davies E.
Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II.
Endocrinology. 2003 Aug;144(8):3321-8.

Lavery GG, Ronconi V, Draper N, Rabbitt EH, Lyons V, Chapman KE, Walker EA, McTernan CL, Giacchetti G, Mantero F, Seckl JR, Edwards CR, Connell JM, Hewison M, Stewart PM.
Late-onset apparent mineralocorticoid excess caused by novel compound heterozygous mutations in the HSD11B2 gene. Hypertension. 2003 Aug;42(2):123-9. Epub 2003 Jul 14.

Draper N, Walker EA, Bujalska IJ, Tomlinson JW, Chalder SM, Arlt W, Lavery GG, Bedendo O, Ray DW, Laing I, Malunowicz E, White PC, Hewison M, Mason PJ, Connell JM, Shackleton CH, Stewart PM.
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
Nat Genet. 2003 Aug;34(4):434-9.

Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J, Ratcliffe P, O'Shea S, Papp J, Taylor E, Dobson R, Knight J, Newhouse S, Hooper J, Lee W, Brain N, Clayton D, Lathrop GM, Farrall M, Connell J;
MRC British Genetics of Hypertension Study. Genome-wide mapping of human loci for essential hypertension.
Lancet. 2003 Jun 21;361(9375):2118-23.

Morrow VA, Foufelle F, Connell JM, Petrie JR, Gould GW, Salt IP. Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells.
J Biol Chem. 2003 Aug 22;278(34):31629-39. Epub 2003 Jun 04.

Perry CG, Palmer T, Cleland SJ, Morton IJ, Salt IP, Petrie JR, Gould GW, Connell JM.
Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action.
Clin Sci (Lond). 2003 Aug;105(2):187-94.

Connell JM, Fraser R, MacKenzie S, Davies E.
Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension?
Hypertension. 2003 May;41(5):993-9. Epub 2003 Mar 24. Review.

Salt IP, Morrow VA, Brandie FM, Connell JM, Petrie JR.
High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser1177 phosphorylation in human aortic endothelial cells.
J Biol Chem. 2003 May 23;278(21):18791-7. Epub 2003 Mar 18.

Swan L, Birnie DH, Padmanabhan S, Inglis G, Connell JM, Hillis WS.
The genetic determination of left ventricular mass in healthy adults. Eur Heart J. 2003 Mar;24(6):577-82.

MacKenzie SM, Fraser R, Connell JM, Davies E.
Local renin-angiotensin systems and their interactions with extra-adrenal corticosteroid production.
J Renin Angiotensin Aldosterone Syst. 2002 Dec;3(4):214-21. Review.

Shakerdi LA, Connell JM, Fraser R, Wallace AM.
Analysis of biological samples by gas chromatography-mass spectrometry without a reference standard: measurement of urinary 18-hydroxytetrahydro-11-dehydrocorticosterone excretion rate in human subjects.
J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Feb 5;784(2):367-73.

Swan L, Birnie DH, Inglis G, Connell JM, Hillis WS.
The determination of carotid intima medial thickness in adults--a population-based twin study.
Atherosclerosis. 2003 Jan;166(1):137-41.

MacKenzie SM, Lai M, Clark CJ, Fraser R, Gomez-Sanchez CE, Seckl JR, Connell JM, Davies E.
11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons.
J Mol Endocrinol. 2002 Dec;29(3):319-25.

Stanton T, Inglis GC, Padmanabhan S, Dominiczak AF, Jardine AG, Connell JM.
Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure.
J Nephrol. 2002 Sep-Oct;15(5):512-8.

Draper N, Echwald SM, Lavery GG, Walker EA, Fraser R, Davies E, Sorensen TI, Astrup A, Adamski J, Hewison M, Connell JM, Pedersen O, Stewart PM.
Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism.
J Clin Endocrinol Metab. 2002 Nov;87(11):4984-90. Lim PO,

Macdonald TM, Holloway C, Friel E, Anderson NH, Dow E, Jung RT, Davies E, Fraser R, Connell JM.
Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio.
J Clin Endocrinol Metab. 2002 Sep;87(9):4398-402.

Padmanabhan N, Padmanabhan S, Connell JM.
Genetic basis of cardiovascular disease--the renin-angiotensin-aldosterone system as a paradigm.
J Renin Angiotensin Aldosterone Syst. 2000 Dec;1(4):316-24. Review. No abstract available.

Charchar FJ, Tomaszewski M, Padmanabhan S, Lacka B, Upton MN, Inglis GC, Anderson NH, McConnachie A, Zukowska-Szczechowska E, Grzeszczak W, Connell JM, Watt GC, Dominiczak AF.
The Y chromosome effect on blood pressure in two European populations.
Hypertension. 2002 Feb;39(2 Pt 2):353-6.

McDonald JE, Padmanabhan N, Petrie MC, Hillier C, Connell JM, McMurray JJ.
Vasoconstrictor effect of the angiotensin-converting enzyme-resistant, chymase-specific substrate [Pro(11)(D)-Ala(12)] angiotensin I in human dorsal hand veins: in vivo demonstration of non-ace production of angiotensin II in humans.
Circulation. 2001 Oct 9;104(15):1805-8.

Fisher A, Friel EC, Bernhardt R, Gomez-Sanchez C, Connell JM, Fraser R, Davies E.
Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11beta-hydroxylase.
J Clin Endocrinol Metab. 2001 Sep;86(9):4326-9.

James DJ, Cairns F, Salt IP, Murphy GJ, Dominiczak AF, Connell JM, Gould GW.
Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin.
Diabetes. 2001 Sep;50(9):2148-56.

Davies E, Holloway CD, Ingram MC, Friel EC, Inglis GC, Swan L, Hillis WS, Fraser R, Connell JM.
An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects.
Clin Endocrinol (Oxf). 2001 Jun;54(6):813-7.

McKenzie CA, Abecasis GR, Keavney B, Forrester T, Ratcliffe PJ, Julier C, Connell JM, Bennett F, McFarlane-Anderson N, Lathrop GM, Cardon LR.
Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE).
Hum Mol Genet. 2001 May 1;10(10):1077-84.

Petrie MC, Padmanabhan N, McDonald JE, Hillier C, Connell JM, McMurray JJ.
Angiotensin converting enzyme (ACE) and non-ACE dependent angiotensin II generation in resistance arteries from patients with heart failure and coronary heart disease.
J Am Coll Cardiol. 2001 Mar 15;37(4):1056-61.

Collison M, Glazier AM, Graham D, Morton JJ, Dominiczak MH, Aitman TJ, Connell JM, Gould GW, Dominiczak AF.
Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat.
Diabetes. 2000 Dec;49(12):2222-6.

Salt IP, Connell JM, Gould GW.
5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes. 2000 Oct;49(10):1649-56.

Petrie JR, Morris AD, Ueda S, Small M, Donnelly R, Connell JM, Elliott HL.
Trandolapril does not improve insulin sensitivity in patients with hypertension and type 2 diabetes: a double-blind, placebo-controlled crossover trial.
J Clin Endocrinol Metab. 2000 May;85(5):1882-9.

Clark CJ, Davies E, Anderson NH, Farmer R, Friel EC, Fraser R, Connell JM.
Alpha-adducin and angiotensin I-converting enzyme polymorphisms in essential hypertension.
Hypertension. 2000 Dec;36(6):990-4. A





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