MRC BRIGHT STUDY LOGO MRC Bright Study banner

Study Background

What is Hypertension?

Resource Information

Patient Resources

National DNA repository

Recruitment Procedures
Acknowledgements

Contact us

Genome Screen Results

Investigators

Nursing and Scientific Teams

Journal Club


start page     |    register     |    log-in    |    software

Professor Patricia Munroe (pubs from 1996)

Book chapters
C.A. Mein, M.J. Caulfield, P.B. Munroe.
Selection of candidate genes in hypertension.
In "Methods MolMed". 108: 107-130.

S.J. Newhouse, S. Huq, G. Arunachalam, M.J. Caulfield, P. B. Munroe.
Genetics of Hypertension.
In "Handbook of Hypertension: Principles and Practice" 4:47-65.

C. Wallace, M. Xue, M. Caulfield, P. B. Munroe.
Genome scans in Hypertension.
In "Handbook of Hypertension".
In press.

B. Burke, J. Gungadoo, A.C.B. Marçano, S.J. Newhouse, J. Shiel, M.J. Caulfield, P.B. Munroe.
Monogenic forms of hypertension.
In "Comprehensive Hypertension",
In press.

Review articles
A.C.B. Marcano, A.K. Onipinla, M. J. Caulfield, P.B. Munroe.
Recent advances in the identification of genes for human hypertension.
Expert Review of Cardiovascular Therapy. 2005 Jul;3(4):733-41.

Original articles
Genome-wide association study identifies novel genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia
Am J Hum Genet. 2008 Jan 10; 82(1) pp. 139 - 149
Chris Wallace; Stephen J Newhouse; Peter Braund; Feng Zhang; Martin Tobin; Mario Falchi; Kourosh Ahmadi; Richard J Dobson; Ana Carolina B Marçano; Cother Hajat; Paul Burton; Panagiotis Deloukas; Morris Brown; John M Connell; Anna Dominiczak; G Mark Lathrop; John Webster; The Wellcome Trust Case Control Consortium; Martin Farrall; Tim Spector; Nilesh J Samani; Mark J Caulfield; Patricia B. Munroe

Genomewide association analysis of coronary artery disease.
N Engl J Med. 2007 Aug 2;357(5):443-53. Epub 2007 Jul 18.
Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H, WTCCC

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
J Med Genet. 2007 Jun 8; [Epub ahead of print]
Braga Marcano AC, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D, Brown M, Dominiczak A, Connell JM, Webster J, Lathrop M, Caulfield M, Samani N, Gauguier D, Munroe PB.

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Nature. 2007 Jun 7;447(7145):661-78.
Wellcome Trust Case Control Consortium.

Chris Wallace, Ming-Zhan Xue, Stephen J. Newhouse, Ana Carolina B. Marçano, Abiodun K. Onipinla, Beverley Burke, Johannie Gungadoo, Richard J. Dobson, Morris Brown, John M. Connell, Anna Dominiczak, G. Mark Lathrop, John Webster, Martin Farrall, Charles Mein, Nilesh J. Samani, Mark J. Caulfield, David G. Clayton, and Patricia B. Munroe
Linkage Analysis Using Co-Phenotypes in the BRIGHT Study Reveals Novel Potential Susceptibility Loci for Hypertension.
Am J Hum Genet. 2006 Aug;79(2):323-31. Epub 2006 Jun 19.

Munroe PB, Wallace C, Xue MZ, B Marcano AC, Dobson RJ, Onipinla AK, Burke B, Gungadoo J, Newhouse SJ, Pembroke J, Brown M, Dominiczak AF, Samani NJ, Lathrop M, Connell J, Webster J, Clayton D, Farrall M, Mein CA, Caulfield M Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study.
Hypertension. 2006 Jun 5; [Epub ahead of print]


RJ Dobson, PB Munroe, MJ Caulfield, MAS Saqi.
Predicting deleterious nsSNPs: an analysis of sequence and structural attributes.
BMC Bioinformatics, 2006 Apr 21;7(1):217 [Epub ahead of print].

Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D, Samani N, Dominiczak A, Webster J, Lathrop GM, Connell J, Munroe P, Caulfield M, Farrall M.
Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension.
Hum Mol Genet. 2006 Apr 15;15(8):1365-74. Epub 2006 Mar 16

Binder A, Garcia E, Wallace C, Gbenga K, Ben-Shlomo Y, Yarnell J, Brown P, Caulfield M, Skrabal F, Kotanko P, Munroe P.
Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study.
J Hypertens. 2006 Mar;24(3):471-477.

Sandosh Padmanabhan PhD, Chris Wallace Ph.D, Patricia B. Munroe Ph.D, Richard Dobson BSc, Morris Brown F.R.C.P, Nilesh Samani F.R.C.P, David Clayton B.A, Martin Farrall FRCPath, John Webster F.R.C.P, Mark Lathrop Ph.D, Mark Caulfield F.R.C.P, Anna F. Dominiczak F.R.C.P, John M. Connell F.R.C.P.
Chromosome 2p shows significant linkage to anti-hypertensive response in the British Genetics of Hypertension (BRIGHT) study.
Hypertension. 2006 Mar;47(3):603-8. Epub 2006 Jan 3.

M.D.Tobin, S. M. Raleigh, S. Newhouse, P. Braund, C. Bodycote, J. Ogleby, D. Cross, S. Hayes, T. Smith, J. Gracey, C. Ridge, M. Caulfield, P. B. Munroe, P. R. Burton, N. J. Samani.
Association of PRKWNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population.
Circulation. 2005 Nov 29;112(22):3423-9. Epub 2005 Nov 21.

S.J. Newhouse, C. Wallace, R. Dobson, C. Mein, J. Pembroke, M. Farrall, D. Clayton, M. Brown, N. Samani, A. Dominiczak, J.M. Connell, J. Webster, G.M. Lathrop, M. Caulfield, P. B. Munroe.
Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension (BRIGHT) study.
Human Molecular Genetics. Jul 1;14(13):1805-14. Epub 2005 May 11.

Marcano AC, Onipinla AK, Caulfield MJ, Munroe PB.
Recent advances in the identification of genes for human hypertension.
Expert Rev Cardiovasc Ther. 2005 Jul;3(4):733-41.

Mein CA, Caulfield MJ, Dobson RJ, Munroe PB.
Genetics of essential hypertension.
Hum Mol Genet. 2004 Apr 1;13 Suppl 1:R169-75.

Garcia EA, Newhouse S, Caulfield MJ, Munroe PB.
Genes and hypertension.
Curr Pharm Des. 2003;9(21):1679-89.

Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J, Ratcliffe P, O'Shea S, Papp J, Taylor E, Dobson R, Knight J, Newhouse S, Hooper J, Lee W, Brain N, Clayton D, Lathrop GM, Farrall M, Connell J; MRC British Genetics of Hypertension Study.
Genome-wide mapping of human loci for essential hypertension. Lancet. 2003 Jun 21;361(9375):2118-23.

Munroe PB; Editorial Board.
Hypercholesterolaemia and vascular function: is the p22phox gene the missing link?
Clin Sci (Lond). 2003 Jul;105(1):11-2.

Knight J, Munroe PB, Pembroke JC, Caulfield MJ.
Human chromosome 17 in essential hypertension.
Ann Hum Genet. 2003 Mar;67(Pt 2):193-206.

Leung KY, Greene ND, Munroe PB, Mole SE.
Identification of a transactivation motif in the CLN3 protein.
IUBMB Life. 2001 May;51(5):295-8.

Leung KY, Greene ND, Munroe PB, Mole SE.
Analysis of CLN3-protein interactions using the yeast two-hybrid system.
Eur J Paediatr Neurol. 2001;5 Suppl A:89-93.

Metherell LA, Akker SA, Munroe PB, Rose SJ, Caulfield M, Savage MO, Chew SL, Clark AJ.
Pseudoexon activation as a novel mechanism for disease resulting in atypical growth-hormone insensitivity.
Am J Hum Genet. 2001 Sep;69(3):641-6.

Munroe PB, Knight J, Caulfield MJ.
1990-2000: progress in determining high blood pressure genes. Ann Acad Med Singapore. 2000 May;29(3):357-63.

Eksandh LB, Ponjavic VB, Munroe PB, Eiberg HE, Uvebrant PE, Ehinger BE, Mole SE, Andreasson S.
Full-field ERG in patients with Batten/Spielmeyer-Vogt disease caused by mutations in the CLN3 gene.
Ophthalmic Genet. 2000 Jun;21(2):69-77.

Munroe PB, Caulfield MJ.
Genetics of hypertension.
Curr Opin Genet Dev. 2000 Jun;10(3):325-9.

Mole SE, Mitchison HM, Munroe PB.
Molecular basis of the neuronal ceroid lipofuscinoses: mutations in CLN1, CLN2, CLN3, and CLN5.
Hum Mutat. 1999;14(3):199-215.

Lauronen L, Munroe PB, Jarvela I, Autti T, Mitchison HM, O'Rawe AM, Gardiner RM, Mole SE, Puranen J, Hakkinen AM, Kirveskari E, Santavuori P.
Delayed classic and protracted phenotypes of compound heterozygous juvenile neuronal ceroid lipofuscinosis.
Neurology. 1999 Jan 15;52(2):360-5.

Munroe PB, Olgunturk RO, Fryns JP, Van Maldergem L, Ziereisen F, Yuksel B, Gardiner RM, Chung E.
Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome.
Nat Genet. 1999 Jan;21(1):142-4

Munroe PB, Strautnieks SS, Farrall M, Daniel HI, Lawson M, DeFreitas P, Fogarty P, Gardiner RM, Caulfield M.
Absence of linkage of the epithelial sodium channel to hypertension in black Caribbeans.
Am J Hypertens. 1998 Aug;11(8 Pt 1):942-5.

Mitchison HM, Hofmann SL, Becerra CH, Munroe PB, Lake BD, Crow YJ, Stephenson JB, Williams RE, Hofman IL, Taschner PE, Martin JJ, Philippart M, Andermann E, Andermann F, Mole SE, Gardiner RM, O'Rawe AM.
Mutations in the palmitoyl-protein thioesterase gene (PPT; CLN1) causing juvenile neuronal ceroid lipofuscinosis with granular osmiophilic deposits.
Hum Mol Genet. 1998 Feb;7(2):291-7. Erratum in: Hum Mol Genet 1998 Apr;7(4):765.

Caulfield M, Bouloux PM, Munroe P.
Progress in determining the genes for hypertension, insulin resistance, and dyslipidemia.
Ann N Y Acad Sci. 1997 Sep 20;827:110-7.

Munroe PB, Mitchison HM, O'Rawe AM, Anderson JW, Boustany RM, Lerner TJ, Taschner PE, de Vos N, Breuning MH, Gardiner RM, Mole SE.
Spectrum of mutations in the Batten disease gene, CLN3.
Am J Hum Genet. 1997 Aug;61(2):310-6.

Mitchison HM, Munroe PB, O'Rawe AM, Taschner PE, de Vos N, Kremmidiotis G, Lensink I, Munk AC, D'Arigo KL, Anderson JW, Lerner TJ, Moyzis RK, Callen DF, Breuning MH, Doggett NA, Gardiner RM, Mole SE.
Genomic structure and complete nucleotide sequence of the Batten disease gene, CLN3.
Genomics. 1997 Mar 1;40(2):346-50.

Munroe PB, O'Rawe AM, Mitchison HM, Jarvela IE, Santavuori P, Lerner TJ, Taschner PE, Gardiner RM, Mole SE.
Strategy for mutation detection in CLN3: characterisation of two Finnish mutations.
Neuropediatrics. 1997 Feb;28(1):15-7.

Mitchison HM, Taschner PE, Kremmidiotis G, Callen DF, Doggett NA, Lerner TJ, Janes RB, Wallace BA, Munroe PB, O'Rawe AM, Gardiner RM, Mole SE.
Structure of the CLN3 gene and predicted structure, location and function of CLN3 protein.
Neuropediatrics. 1997 Feb;28(1):12-4.

Daniel HI, Munroe PB, Kamdar SM, Lawson M, Lavender P, Forgaty P, Caulfield MJ.
The atrial natriuretic peptide gene and essential hypertension in African-Caribbeans from St Vincent and the Grenadines.
J Hum Hypertens. 1997 Feb;11(2):113-7.

Janes RW, Munroe PB, Mitchison HM, Gardiner RM, Mole SE, Wallace BA.
A model for Batten disease protein CLN3: functional implications from homology and mutations.
FEBS Lett. 1996 Dec 9;399(1-2):75-7.

Jarvela I, Mitchison HM, Munroe PB, O'Rawe AM, Mole SE, Syvanen AC.
Rapid diagnostic test for the major mutation underlying Batten disease.
J Med Genet. 1996 Dec;33(12):1041-2.

Munroe PB, Rapola J, Mitchison HM, Mustonen A, Mole SE, Gardiner RM, Jarvela I.
Prenatal diagnosis of Batten's disease.
Lancet. 1996 Apr 13;347(9007):1014-5.

 

 

MRC Bright Study small image

 



r.j.dobson@qmul.ac.uk
hi